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| Zdroj: |
Genomics & Genetics Weekly; 3/22/2024, p1884-1884, 1p |
| Abstrakt: |
A recent study conducted by researchers from the University of Birmingham in the United Kingdom explores the use of conjunctival genetic transcriptomic analyses as a potential tool for understanding the signaling pathways involved in Ocular Mucous Membrane Pemphigoid (OcMMP). The study analyzed the RNA profiles of conjunctival swabs from MMP patients and age-matched control participants using the NanoString nCounter Human Fibrosis panel. The researchers identified 93 differentially expressed genes (DEGs) between OcMMP and controls, with 48 upregulated and 45 downregulated. The study also found that profibrotic genes were more prevalent in the OcMMP group, and certain pathways related to extracellular matrix remodeling were accentuated in eyes with visible inflammation. The researchers suggest that further longitudinal sampling and investigation will provide more insight into the disease and the development of biomarkers to monitor its progression. [Extracted from the article] |
| Databáze: |
Complementary Index |
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