Localised intravascular coagulation complicating venous malformations: Clinical characterisation.
| Autor: | Blaise, Sophie, Soya, Esaie, Nou, Monira, Malloizel-Delaunay, Julie, Thiel, Hélène, Bisdorff-Bresson, Annouk, Seinturier, Christophe |
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| Předmět: |
RISK assessment
ANTICOAGULANTS VEINS DISSEMINATED intravascular coagulation SCIENTIFIC observation SYMPTOMS FIBRIN fibrinogen degradation products DESCRIPTIVE statistics RESEARCH FIBRINOGEN COMPARATIVE studies BLOOD-vessel abnormalities REGRESSION analysis THROMBOSIS DISEASE risk factors DISEASE complications |
| Zdroj: | Phlebology; Apr2024, Vol. 39 Issue 3, p169-173, 5p |
| Abstrakt: | Objective: The International Union of Phlebology recommends measuring at least D-dimer and fibrinogen levels in the diagnosis of extensive extra-truncular venous malformations, with a surface area of 10 cm2 or those which are deep, as well as prior to any interventional procedure. The aim of the study was to characterise venous malformations associated with a possible vascular complication. Method: This study was an observational and multicentre study. The objective was to explore the presence of a possible coagulation disorder among patients with venous malformation. The primary endpoint was to characterise venous malformations with increased D-dimer levels. Results: The majority of the 72 venous malformations were located in the trunk region, mostly in intramuscular or subcutaneous locations. There were 72 venous malformations with increased D-dimer levels including 3 with biological disseminated intravascular coagulation (elevated D-dimer and fibrinogen <1 g/L). The anticoagulant treatments administered were very heterogeneous in class and dosage, and at the end of the treatment, 17 elevated D-dimers were persistent, 9 venous malformations remained painful and 27 showed thrombotic regression. Conclusion: Venous vascular malformations are probably underestimated and should probably be explored more systematically in terms of coagulation disorder regardless of size or symptomatology. The therapeutic recommendations to treat localised intravascular coagulation with low-molecular weight are not widely applied. Studies are needed, in particular to assess the role of oral anticoagulants in the management of coagulation disorder among patients with venous malformation. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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