| Autor: |
Kumamoto, Hiroki, Imoto, Shuhei, Kuwata-Higashi, Nobuyo, Mitsuya, Hiroaki, Haraguchi, Kazuhiro |
| Předmět: |
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| Zdroj: |
Synlett; Apr2024, Vol. 35 Issue 6, p728-733, 6p |
| Abstrakt: |
This article discusses the synthesis and evaluation of the anti-hepatitis B virus (HBV) activity of novel nucleoside derivatives. Hepatitis B is a prevalent viral disease that affects millions of people worldwide and can lead to chronic disease and liver cancer. The article describes the synthesis of a 2'-deoxy-4'-thioguanosine derivative with a cyano group at the 4'-position, which exhibited significantly more potent anti-HBV activity than the parent nucleoside. This finding could guide the development of new anti-HBV agents. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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