| Autor: |
Hudait, Nandagopal, Sakander, Norein, Kundu, Sanchari, Rasool, Bisma, Sengupta, Jhimli, Mukherjee, Debaraj |
| Předmět: |
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| Zdroj: |
Synlett; Apr2024, Vol. 35 Issue 6, p635-648, 14p |
| Abstrakt: |
This article provides a concise overview of the synthesis and significance of modified C-nucleosides in medicinal chemistry. C-nucleosides, which are more resistant to hydrolysis than N-nucleosides, have various applications in drug design and chemical biology. The article discusses the development of synthetic methodologies for C-nucleoside analogues and their role as inhibitors of purine nucleoside phosphorylase or IMP dehydrogenase. It also highlights the use of nucleoside analogues in chemotherapy, gene expression inhibition, and other therapeutic strategies. The article concludes with a discussion of different synthetic strategies and the importance of C-nucleoside scaffolds in biology and medicine. The text explores various methods for the synthesis of C-nucleoside analogues, including the use of carbon nucleophiles and intermolecular cyclization. Specific compounds, such as showdomycin and pseudouridimycin, are mentioned for their potential applications in medicinal chemistry and chemical biology. The development of efficient and selective techniques for C-glycosidation processes is still ongoing, but these methods show promise for the synthesis of new molecules and the discovery of new properties and modes of action. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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