IDIOPATHIC GRANULOMATOUS MASTITIS: MULTICENTER STUDY.
| Autor: | Ermurat, Selime, Aydoğdu, Mesude Seda, Altuner, Mehmet Şakir, Zontul, Sezgin, Cüre, Osman, Albayrak, Fatih, Zengin, Orhan, Kudaş, Özlem, İnanç, Elif, Yolbaş, Servet, Akyol, Lütfi, Ertaş, Şule Ketenci, Babaoğlu, Hakan, Balcı, Mehmet Ali, Savaş, Yılmaz, Karataş, Ahmet, Artaş, Hakan, Kısacık, Bünyamin, Koca, Süleyman Serdar |
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| Předmět: |
ANTIBIOTICS
ADRENOCORTICAL hormones NONSTEROIDAL anti-inflammatory agents NIPPLE discharge WEIGHT loss ERYTHEMA nodosum GRANULOMA DRUG side effects ERYTHEMA METHOTREXATE FISHER exact test TREATMENT effectiveness RETROSPECTIVE studies COLCHICINE DESCRIPTIVE statistics FEVER CHI-squared test MULTIVARIATE analysis AZATHIOPRINE SKIN abnormalities PAIN JOINT pain MAMMOGRAMS STATISTICS MASTITIS DISEASE relapse DATA analysis software COMPARATIVE studies TUMOR necrosis factors REGRESSION analysis |
| Zdroj: | Rheumatology Quarterly; Mar2024, Vol. 2 Issue 1, p31-39, 9p |
| Abstrakt: | Objectives: Idiopathic granulomatous mastitis (IGM) is a rare, benign, chronic inflammatory breast disease of unknown etiology. There is no standardized treatment because its etiology is still unclear. In this multicenter study, we presented the demographic, treatment, and follow-up characteristics of IGM cases monitored by rheumatology clinics. Material and Methods: This retrospective study was conducted in 13 different rheumatology centers. A total of 108 patients with IGM were included in the study. Demographic and clinical data were retrospectively obtained from patient files. Results: The most commonly administered drugs were, in order of frequency, corticosteroid (CS) (91.7%), methotrexate (MTX) (74.1%), antibiotics (63%), non-steroidal anti-inflammatory drugs (41.7%), azathioprine (AZA) (13.9%), colchicine (5.6%), and tumor necrosis factor (TNF) inhibitors (0.9%). The most commonly used form of immunosuppressive (IS) treatment was the MTX and CS combination 78 (72.2%). The ratio of patients receiving CS alone was 19 (17.6%). The ratio of patients who were operated on only and did not use IS drugs was 6.5%. The ratio of patients who received no treatment was 2.8%. Among the drugs used, MTX and CS alone use were independent risk factors for relapse; (p=0.027, p=0.011, respectively). The relapse rate was higher in patients receiving CS alone. Conclusion: IS drugs including CS, MTX, AZA, and TNF inhibitors seem to be efficient for treating IGM. CS alone use is associated with relapse, and the use of other IS drugs such as MTX is particularly effective in reducing relapse in IGM. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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