| Autor: |
Bazylev, Vladlen, Voevodin, Andrey, Kuznetsova, Alyona, Premal, Mihir |
| Předmět: |
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| Zdroj: |
E Journal of Cardiovascular Medicine; 2023 Supplement, Vol. 11, p1-1, 1p |
| Abstrakt: |
Aim of study: Research of the clinical and hemodynamic results of transcatheter replacement of the aortic valve with the prosthesis containing polytetrafluoroethylene cusps. Methods. "MedLab-CT" is the first model of a transcatheter prosthetic with PTFE leaflets. It is a balloonexpandable stent, the cusps of which are made of 0.1 mm thick PTFE plates. The reason of choice of synthetic material was the hypothesis of the absence of biodegradation of PTFE. The valve has passed the preclinical phases of the in vitro and in vivo tests. The study included 523 patients who had undergone implantation of the "MedLab-CT" prosthesis. The survival rate, as well as hemodynamic parameters according to echocardiography for up to 7 years, were evaluated. 287 patients were examined in person, the rest went through a telephone survey. Results. The 7-years follow-up was conducted. The majority of patients belonged to the elderly group (mean age 74.3 years). For 246 patients (47 %) according to the EuroSCORE II scale a high risk of surgical intervention was determined. 7-yaers survival was 62%; 22 (5%) deaths were noted at the hospital stage, 31 patients died in the long-term period. 6 (1.1%) strokes were recorded. In the personal examination group, the average gradient on the aortic valve prosthesis is defined at 9.2 ±3.9 mm Hg; insufficiency due to paraprosthetic fistulas not higher than I degree was noted in 124 patients (43 %), not higher than II degree in 3 (1%) case; transvalvular aortic regurgitation was not detected. Conclusion. 7-year results of using aortic valve with PTFE leaflets are not inferior to data using known TAVI models. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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