| Autor: |
Dinh, Paul C, Monahan, Patrick O, Fosså, Sophie D, Sesso, Howard D, Feldman, Darren R, Dolan, M Eileen, Nevel, Kathryn, Kincaid, John, Vaughn, David J, Martin, Neil E, Sanchez, Victoria A, Einhorn, Lawrence H, Frisina, Robert, Fung, Chunkit, Kroenke, Kurt, Travis, Lois B |
| Předmět: |
|
| Zdroj: |
JNCI: Journal of the National Cancer Institute; Mar2024, Vol. 116 Issue 3, p455-467, 13p |
| Abstrakt: |
Background No study has quantified the impact of pain and other adverse health outcomes on global physical and mental health in long-term US testicular cancer survivors or evaluated patient-reported functional impairment due to pain. Methods Testicular cancer survivors given cisplatin-based chemotherapy completed validated surveys, including Patient-Reported Outcomes Measurement Information System v1.2 global physical and mental health, Patient-Reported Outcomes Measurement Information System pain questionnaires, and others. Multivariable linear regression examined relationships between 25 adverse health outcomes with global physical and mental health and pain-interference scores. Adverse health outcomes with a β ^ of more than 2 are clinically important and reported below. Results Among 358 testicular cancer survivors (median age = 46 years, interquartile range [IQR] = 38–53 years; median time since chemotherapy = 10.7 years, IQR = 7.2–16.0 years), median adverse health outcomes number was 5 (IQR = 3–7). A total of 12% testicular cancer survivors had 10 or more adverse health outcomes, and 19% reported chemotherapy-induced neuropathic pain. Increasing adverse health outcome numbers were associated with decreases in physical and mental health (P < .0001 each). In multivariable analyses, chemotherapy-induced neuropathic pain ( β ^ = −3.72; P = .001), diabetes ( β ^ = −4.41; P = .037), obesity ( β ^ = −2.01; P = .036), and fatigue ( β ^ = −8.58; P < .0001) were associated with worse global mental health, while being married or living as married benefited global mental health ( β ^ = 3.63; P = .0006). Risk factors for pain-related functional impairment included lower extremity location ( β ^ = 2.15; P = .04) and concomitant peripheral artery disease ( β ^ = 4.68; P < .001). Global physical health score reductions were associated with diabetes ( β ^ = −3.81; P = .012), balance or equilibrium problems ( β ^ = −3.82; P = .003), cognitive dysfunction ( β ^ = −4.43; P < .0001), obesity ( β ^ = −3.09; P < .0001), peripheral neuropathy score ( β ^ = −2.12; P < .0001), and depression ( β ^ = −3.17; P < .0001). Conclusions Testicular cancer survivors suffer adverse health outcomes that negatively impact long-term global mental health, global physical health, and pain-related functional status. Clinically important factors associated with worse physical and mental health identify testicular cancer survivors requiring closer monitoring, counseling, and interventions. Chemotherapy-induced neuropathic pain must be addressed, given its detrimental impact on patient-reported functional status and mental health 10 or more years after treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
