Hypercalcaemia of malignancy: a case of vitamin-D- mediated hypercalcaemia in lymphoma.

Autor: Mehta, Kanchi, Awan, Maham, Devlin, Shannon, Jassal, Simerjot Kaur
Zdroj: BMJ Case Reports; Feb2024, Vol. 17 Issue 2, p1-3, 3p
Abstrakt: Hypercalcaemia of malignancy (HCM) is a paraneoplastic syndrome that often portends a poor prognosis. We present an extremely rare (<1%) case of HCM due to extrarenal calcitriol (1,25-( OH)2D) production in a patient with splenic marginal zone lymphoma. A man in his 80s presented with a 3-week history of fatigue, unsteadiness and abdominal pain, and new findings of anaemia, kidney injury and hypercalcaemia. Laboratory evaluation, bone marrow biopsy and positron emission tomography/computed tomography (PET/CT) confirmed the diagnosis of splenic marginal zone lymphoma which produced calcitriol (1,25-( OH)2D3), causing the patient’s hypercalcaemia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index