Radboud University Researcher Describes Recent Advances in Autism Spectrum Disorders (D1-Like and D2-Like Dopamine Receptors in the Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits).

Předmět:	AUTISM spectrum disorders DOPAMINE receptors PREFRONTAL cortex RESEARCH personnel CENTRAL nervous system diseases
Zdroj:	Mental Health Weekly Digest; 3/15/2024, p1577-1577, 1p
Abstrakt:	A recent study conducted by researchers at Radboud University in the Netherlands explores the involvement of the prefrontal cortical dopaminergic system in the psychopathology of epilepsy and comorbid conditions such as autism spectrum disorder (ASD). The study used autoradiography to examine the D1-like and D2-like receptor binding density in the prefrontal cortex of rats with different forms of epilepsy. The results showed significant decreases in binding densities to both D1-like and D2-like receptors in the prefrontal cortex of rats with epilepsy, with specific changes observed in the lateral prefrontal cortex of rats with an ASD-like phenotype. These findings suggest potential local dopaminergic dysfunctions associated with epilepsy and ASD. [Extracted from the article]
Databáze:	Complementary Index
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