| Abstrakt: |
A recent study conducted at Carnegie Mellon University explores the impact of spatial structure on the evolution of solid tumors and the composition of circulating tumor DNA (ctDNA). The researchers found that chemotherapy and immune infiltration can lead to variable rates of cell death in solid tumors, which can bias and distort the clonal composition of ctDNA. This spatial bias in shedding can result in highly biased profiles of tumor state in liquid biopsies, potentially increasing the risk of targeting subclonal variants for treatment. The study highlights the need for further research on the effects of spatially variable cell death on ctDNA composition. [Extracted from the article] |
