| Abstrakt: |
A study conducted by researchers at Shanghai Jiao Tong University in China explores the potential of bioengineering islet organoids as a treatment for insulin-dependent diabetes. The researchers highlight the advantages of this approach over cadaveric islet transplantation but also acknowledge the challenges, such as immature endocrine function and the absence of a perfusable vasculature. The study discusses the latest developments in bioengineering functional islet organoids and promoting vascularization before and after transplantation. The researchers also address considerations that need to be addressed before clinical translation, including functional immaturity, heterogeneity, and potential tumorigenic risks. [Extracted from the article] |
