Investigators at University of Kansas Describe Findings in Acetaminophen Therapy (Spatial Analysis of Renal Acetaminophen Metabolism and Its Modulation By 4-methylpyrazole With Desi Mass Spectrometry Imaging).

Předmět:	FOMEPIZOLE MASS spectrometry ACETAMINOPHEN KIDNEY cortex METABOLISM
Zdroj:	Drug Week; 3/15/2024, p1185-1185, 1p
Abstrakt:	Researchers at the University of Kansas have conducted a study on the metabolism of acetaminophen (APAP) in the kidneys and its modulation by 4-methylpyrazole (4MP). The study found that APAP metabolism in the kidney is dose-dependent and that different regions of the kidney have distinct distributions of APAP metabolites. The researchers also discovered that 4MP can ameliorate these region-specific variations in APAP metabolism. This study provides insight into the mechanisms of APAP-induced nephrotoxicity. [Extracted from the article]
Databáze:	Complementary Index
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