| Abstrakt: |
A recent study conducted at Vanderbilt University Medical Center in Nashville, Tennessee, explored the issue of carbapenem resistance in bacteria due to metallo-beta-lactamases (MBLs) such as the Verona integron-encoded metallo-beta-lactamase (VIM). The researchers described a case series of bacterial infections in a hospital and their experience using novel beta-lactam antibiotics and antibiotic combinations to treat these infections. They found that the combination of ceftazidime-avibactam and aztreonam was effective in treating the infections, but cefiderocol-resistant Klebsiella pneumoniae isolates were detected in some patients who received cefiderocol. Whole-genome sequencing revealed that these isolates had acquired point mutations in certain genes, resulting in increased resistance to cefiderocol. The study highlights the need for diligent monitoring of antibiotic use to prevent the rapid development of resistance. [Extracted from the article] |
