| Autor: |
杨树森, 刘禹杉, 张仪霖, 惠 毅, 李京涛, 闫曙光 |
| Předmět: |
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| Zdroj: |
Chinese Journal of Pathophysiology; Feb2024, Vol. 40 Issue 2, p358-364, 7p |
| Abstrakt: |
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease of unknown etiology, with a rapid disease course, poor prognosis, and the absence of effective therapeutic drugs. Mitochondrial dysfunction is one of the crucial causes of inducing IPF. Silent information regulator 3（SIRT3） can restore mitochondrial homeostasis by inhibiting mitochondrial oxidative stress, repairing mitochondrial DNA damage, and ameliorating abnormal mitochondrial lipid metabolism. This paper summarizes the role and mechanism of SIRT3 in attenuating mitochondrial dysfunction based on delineating the relationship between mitochondrial dysfunction and IPF, aiming to provide references for finding effective treatment methods for IPF. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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