| Autor: |
Hrčková, G., Kubašková, T. Mačak, Jurčacková, Z., Ciglanová, D. |
| Zdroj: |
Slovak Veterinary Journal / Slovenský Veterinársky časopis; 2023, Vol. 48 Issue 2, p117-122, 6p |
| Abstrakt: |
The second larval stage (metacestode) of the tapeworm Mesocestoides (M.) vogae (syn. M. corti) called tetrathyridium reproduces asexually in rodents and some other vertebrate species. After oral infection, metacestodes migrate to the liver and peritoneal cavity, where they cause severe inflammation and fibrosis of the liver. Infection is a suitable model for studying the immunomodulating effects of drugs. The levels of specific IgG and IgM antibodies and dominant Th1/Th2 and T regulatory immune response cytokines were studied at the local level in the peritoneal cavity and at the systemic level in the serum of mice infected with Mesocestoides vogae after the treatment with albendazole, DLE and their combination, and the effectiveness of the treatment. The therapy with an anthelmintic and immunomodulating substance DLE significantly affected IgM antibodies against E/S but also somatic antigens in the peritoneal cavity, where the high est reduction of larvae occurred after combined treatment with both preparations. In this treated group, the concentrations of the cytokine IFN-γ significantly increased and, conversely, the concentrations of IL-4 and TGF-β decreased, which indicates the stimulation of Th1 immunity and the reduction of the suppressive mechanisms of Th2 and T regulatory immunity. Monitoring the levels of the mentioned cytokines in the serum is therefore a more sensitive approach for monitoring the effectiveness of the therapy than the determination of IgG and IgM antibodies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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