Genetic studies in clonal haematopoiesis, myelodysplastic neoplasms and acute myeloid leukaemia – a practical guide to WHO-HAEM5.

Autor:	Haferlach 1, Claudia, Haferlach 1, Torsten, Hörst 1, Katharina, Kühn 1, Constanze, Khoury MD 2, Joseph D.
Předmět:	HEMATOPOIESIS MYELODYSPLASTIC syndromes ACUTE myeloid leukemia TUMOR classification
Zdroj:	Medizinische Genetik; Apr2024, Vol. 36 Issue 1, p21-29, 9p
Abstrakt:	In recent years, technology developments and increase in knowledge have led to profound changes in the diagnostics of haematologic neoplasms, particularly myeloid neoplasms. Therefore an updated, fifth edition of the World Health Organization (WHO) classification of haematolymphoid neoplasms (WHO-HAEM5) will be issued in 2024. In this context, we present a practical guide for analysing the genetic aspects of clonal haematopoiesis of indeterminate potential (CHIP), clonal cytopenia of undetermined significance (CCUS), myelodysplastic neoplasms (MDS), and acute myeloid leukaemia (AML) based on WHO-HAEM5. This guide navigates through the genetic abnormalities underlying myeloid neoplasms which are required to be detected for classification according to WHO-HAEM5 and provides diagnostic algorithms. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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