The association between parental SARS-CoV-2 infection in pregnancy and fetal growth restriction.
| Autor: | Mitta, Melanie, Holt, Lauren, Chandrasekaran, Suchitra, Dude, Carolynn |
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| Předmět: |
FETAL growth retardation -- Risk factors
RISK assessment SMALL for gestational age POLYMERASE chain reaction LOGISTIC regression analysis FETAL ultrasonic imaging CHI-squared test DESCRIPTIVE statistics LONGITUDINAL method ODDS ratio GESTATIONAL age PREECLAMPSIA STATISTICS SOCIODEMOGRAPHIC factors BIRTH weight CONFIDENCE intervals COVID-19 PREGNANCY |
| Zdroj: | Journal of Perinatal Medicine; Mar2024, Vol. 52 Issue 3, p317-321, 5p |
| Abstrakt: | Although the relationship between maternal viral infections and fetal growth restriction (FGR) is well established, the association between SARS-CoV-2 infection in pregnancy and FGR remains unclear. We investigated the association between SARS-CoV-2 infection in pregnancy and FGR at a single county hospital. We performed a prospective cohort study with cohorts matched by gestational age and month of SARS-CoV-2 PCR testing between April 2020 and July 2022. Individuals were included if they had a SARS-CoV-2 PCR testing up to 32 weeks of gestation and had a third trimester ultrasound. Primary outcome was a diagnosis of FGR, while secondary outcomes were rates of preeclampsia, small for gestational age (SGA) and birthweight. Univariate analyses, chi-square test and logistic regression were used for analysis. Our cohorts constituted of 102 pregnant individuals with a positive SARS-CoV-2 PCR test result and 103 pregnant individuals with a negative SARS-CoV-2 PCR test result in pregnancy. FGR rates were 17.8 % and 19.42 % among positive and negative SARS-CoV-2 cohorts respectively. While a statistical difference in preeclampsia rates was noted (34.31 % vs. 21.36 %, p=0.038) between cohorts, odds of getting preeclampsia based on SARS-CoV-2 test result was not significant (aOR 1.01, CI=0.97–1.01, p=0.75). No statistical difference was noted in demographics, FGR and SGA rates, and birthweight. Our findings suggest no association between SARS-CoV-2 infection in pregnancy and FGR at a single institution. Our results validate emerging data that additional fetal growth ultrasonographic assessment is not indicated solely based on SARS-CoV-2 infection status. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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