| Autor: |
Gitsomboon, Sawika, Ratanapornsompong, Ganista, Ongphiphadhanakul, Boonsong, Thongpradit, Supranee, Chanprasertyothin, Suwannee, Chailurtkit, La-or, Nimitphong, Hataikarn |
| Předmět: |
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| Zdroj: |
BMC Nutrition; 3/4/2024, Vol. 10 Issue 1, p1-8, 8p |
| Abstrakt: |
Background: Prediabetes is increasing worldwide. Previous studies have demonstrated the potential of β-glucan derived from oat or barley to lower blood glucose, body weight, and plasma lipid levels. These findings offer a potentially attractive strategy for reducing the risk of diabetes in prediabetic individuals. However, the effects of β-glucan from Tremella fuciformis on glucose metabolism and anthropometric measurements in humans have yet to be studied. We hypothesized that β-glucan from Tremella fuciformis may improve metabolic parameters in subjects with prediabetes. This study aimed to investigate the effects of a once-daily beverage containing Tremella fuciformis (snow mushroom) on anthropometric measurements, metabolic biomarkers, and insulin sensitivity in overweight/obese subjects with prediabetes. Methods: In this double-blind RCT, 56 participants were randomly assigned to receive either a Tremella fuciformis beverage or placebo daily for 12 weeks. All parameters were assessed at baseline and after the intervention. Results: After 12 weeks, participants in the intervention group exhibited significant improvements in glycated hemoglobin A1c (HbA1C; 6.03 ± 0.26% at baseline vs. 5.96 ± 0.25% at 12 weeks, p = 0.047, Cohen's d = 0.39) and waist circumference (95.2 ± 12.51 cm at baseline vs. 93.46 ± 11.48 cm at 12 weeks, p = 0.022, Cohen's d = 0.45). There were no adverse events reported. Conclusion: This exploratory study demonstrated that Tremella fuciformis beverage consumption may improve HbA1C and waist circumference in overweight/obese prediabetic individuals. Further research, including larger-scale RCTs and mechanistic studies, is needed to confirm these findings and optimize the therapeutic potential of Tremella fuciformis derivatives in managing prediabetes and preventing type 2 diabetes. Trial registration: Registered in Thai Clinical Trials Registry (14/07/2021, TCTR20210714004). Highlights: Tremella fuciformis contains β-glucan and may have benefit in metabolic syndrome. This is the first RCT exploring the effects of T. fuciformis in overweight/obese prediabetes subjects. Twelve weeks of T. fuciformis consumption reduced HbA1C and waist circumference. No adverse events were reported among subjects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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