Synthesis and in vitro evaluation of 99mTc radiolabeled lapatinib (LPT) and its PLGA formulation.

Autor:	Gokulu, Sevki Goksun, Karatay, Kadriye Busra, Bilgi, Ahmet, Kayas, Cansu, Yildirim, Nuri, Kilcar, Ayfer Yurt, Muftuler, Fazilet Zumrut Biber, Terek, Mustafa Cosan, Akman, Levent
Předmět:	BREAST CELL culture HUMAN cell culture PROTEIN-tyrosine kinase inhibitors LAPATINIB HELA cells CELL lines
Zdroj:	Journal of Radioanalytical & Nuclear Chemistry; Feb2024, Vol. 333 Issue 2, p665-672, 8p
Abstrakt:	Lapatinib-(LPT) is a dual tyrosine kinase inhibitor that has important effects on the targeted therapy of various tumours. The current study is aimed to use a novel tracer strategy including Technetium-99 m-(99mTc) radiolabeled LPT and its poly(lactic-co-glycolic acid)-(PLGA) encapsulated formulation-(LPT-PLGA). In vitro bioaffinity of the [99mTc]Tc-LPT and [99mTc]Tc-LPT-PLGA was evaluated by using cell culture methods on human breast adenocarcinoma (MDA-MB-231), cervix adenocarcinoma and human ovarian (MDAH-2774) cancer cell lines. Radiochemical yield were over 95% and both compounds were examined high incorporation values on HeLa and MDAH cell lines. Current results may contribute to develope as the encapculated agents including radiotracer. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink