| Autor: |
Hamad, J., Shaw, B., Kohen, L., Linos, K., Friedman, B. J. |
| Předmět: |
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| Zdroj: |
Journal of Cutaneous Pathology; Apr2024, Vol. 51 Issue 4, p284-287, 4p |
| Abstrakt: |
This article discusses a study on sclerosing melanocytic tumors with MAP2K1 in-frame deletions and copy number gains in 15q. The study examines the histomorphologic, immunophenotypic, and cytogenetic features of these tumors. The authors found that these tumors can be recognized by the presence of SPARK-like architecture and a desmoplastic Spitz nevus-like appearance. They also observed chromosomal copy number changes, with a gain in chromosome 15 being a common finding. The article suggests that these tumors may represent a distinctive pathway of nevogenesis and further research is needed to understand their biologic potential. [Extracted from the article] |
| Databáze: |
Complementary Index |
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