Prognostic Impact of Blood Lipid Profile in Patients With Advanced Solid Tumors Treated With Immune Checkpoint Inhibitors: A Multicenter Cohort Study.
| Autor: | Pecci, Federica, Cantini, Luca, Cognigni, Valeria, Perrone, Fabiana, Mazzaschi, Giulia, Agostinelli, Veronica, Mentrasti, Giulia, Favari, Elda, Maffezzoli, Michele, Cortellini, Alessio, Rossi, Francesca, Chiariotti, Rebecca, Venanzi, Francesco Maria, Russo, Giuseppe Lo, Galli, Giulia, Proto, Claudia, Ganzinelli, Monica, Tronconi, Francesca, Morgese, Francesca, Campolucci, Carla |
|---|---|
| Předmět: |
LIPID metabolism
THERAPEUTIC use of antineoplastic agents RESEARCH HDL cholesterol TRIGLYCERIDES RENAL cell carcinoma LUNG cancer BLADDER tumors KRUSKAL-Wallis Test STATISTICS IMMUNE checkpoint inhibitors CONFIDENCE intervals MULTIVARIATE analysis MELANOMA LOG-rank test RETROSPECTIVE studies LDL cholesterol HEAD & neck cancer ACQUISITION of data MANN Whitney U Test FISHER exact test CANCER patients RISK assessment PROTEIN-tyrosine kinase inhibitors DESCRIPTIVE statistics SURVIVAL analysis (Biometry) MEDICAL records CHI-squared test KAPLAN-Meier estimator TUMORS PROGRESSION-free survival DATA analysis software ODDS ratio LIPIDS LONGITUDINAL method CHOLESTEROL OVERALL survival BREAST tumors PROPORTIONAL hazards models |
| Zdroj: | Oncologist; Mar2024, Vol. 29 Issue 3, pe372-e381, 10p |
| Abstrakt: | Background Specific components of lipid profile seem to differently impact on immune activity against cancer and unraveling their prognostic role in patients with solid cancer treated with immune checkpoint inhibitors (ICIs) is needed. Materials and Methods We retrospectively collected baseline clinicopathological characteristics including circulating lipid profile (total cholesterol [TC], triglycerides [TG], low-density lipoproteins [LDL], high-density lipoproteins [HDL]) of patients with consecutive solid cancer treated with ICIs, and we investigated their role in predicting clinical outcomes. Results At a median follow-up of 32.9 months, among 430 enrolled patients, those with TC ≥ 200 mg/dl showed longer median progression-free survival (mPFS; 6.6 vs. 4.7 months, P = .4), although not reaching statistical significance, and significantly longer median overall survival (mOS; 19.4 vs. 10.8 months, P = .02) compared to those with TC < 200 mg/dl. Conversely, patients with TG ≥150 mg/dl displayed shorter PFS (3.4 vs. 5.1 months, P = .02) and OS (7.1 vs. 12.9 months, P = .009) compared to those with TG <150 mg/dl. TC and TG were then combined in a "LIPID score" identifying three subgroups: good-risk (GR) (TC ≥200 mg/dl and TG <150 mg/dl), intermediate-risk (IR) (TC <200 mg/dl and TG <150 mg/dl or TC ≥200 mg/dl and TG ≥150 mg/dl) and poor-risk (PR) (TC <200 mg/dl and TG ≥150 mg/dl). The mPFS of GR, IR, and PR groups was 7.8, 4.3, and 2.5 months, respectively (P = .005); mOS of GR, IR, and PR was 20.4, 12.4, and 5.3 months, respectively (P < .001). At multivariable analysis, the PR profile represented an independent poor prognostic factor for both PFS and OS. Conclusions We developed a lipid score that defined subgroups of patients with cancer who differently benefit from ICIs. Further mechanistic insights are warranted to clarify the prognostic and predictive role of lipid profile components in patients treated with ICIs. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|