| Autor: |
BEN SASSI, A., JMII, H., BEN FADHEL, R., AOUNI, M., JAIDANE, H., MASTOURI, M. |
| Předmět: |
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| Zdroj: |
Applied Ecology & Environmental Research; 2024, Vol. 22 Issue 1, p645-664, 20p |
| Abstrakt: |
The aerial part and root extracts of Crucianella angustifolia grown in Tunisia were prepared using aqueous and organic solvents to determine the phenolic contents. Besides, the antioxidant activity was evaluated using the DPPH and ABTS radical scavenging and reduction power tests. The a-glucosidase inhibition activity was assessed using p-nitrophenyl-a-D-glucopyranoside. The antimicrobial activity of the extracts was evaluated on a set of medically important bacterial strains, the fungus Candida albicans and the virus Coxsackivirus B3. The results showed that methanolic and aqueous extractions yielded the highest quantities of polyphenols, flavonoids and flavonols. The obtained extracts exhibited a pronounced antioxidant activity. All methanolic extracts showed the greatest anti-a-glucosidase activity. The methanolic extract exhibited the highest antibacterial effect, while petroleum ether extract was the most effective against C. albicans. The various extracts turned out to be non-toxic on Hep-2 cell line with a CC50>1000 µg/ml for all of them. Petroleum ether extract of aerial part was the most effective against virus with an IC50 equal to 5.92 µg/ml. The unraveled biological activities of C. angustifolia are likely to be attributed to the phenolic constituents contained in the plant. Further studies are needed to depict the components and mechanisms underlying the observed biological effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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