| Abstrakt: |
A report from Sapienza University of Rome discusses the evolution of Klebsiella pneumoniae sequence type 512 during treatment with ceftazidime/avibactam, meropenem/vaborbactam, and cefiderocol. The study focuses on a critically ill patient who was colonized with a carbapenem-resistant strain of K. pneumoniae and received these antibiotics to treat respiratory tract infections. The research found that the therapies altered the resistome of the bacteria, leading to resistance to cefiderocol. The study highlights the potential for cross-selection between K. pneumoniae and other infectious agents, emphasizing the importance of monitoring and addressing the evolution of antibiotic resistance in public health. [Extracted from the article] |
