Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients.

Autor:	Yiğit, Yasemin Demir, Karatoprak, Özlem Karakuş, Ay, Elif Güzelsoy, Karabulut, Muhammed, Yılmaz, Erdal, Gürgöze, Metin Kaya
Předmět:	CARDIOVASCULAR diseases risk factors PATIENT aftercare PERICARDITIS VENTRICULAR ejection fraction HEART PERICARDIUM INFLAMMATION PEDIATRICS CARDIAC contraction MANN Whitney U Test RISK assessment PEDIATRIC cardiology T-test (Statistics) CARDIAC output DESCRIPTIVE statistics CHI-squared test DATA analysis software AUTOINFLAMMATORY diseases OUTPATIENT services in hospitals COMORBIDITY DISEASE risk factors DISEASE complications
Zdroj:	Egyptian Rheumatology & Rehabilitation; 2/26/2024, Vol. 51 Issue 1, p1-7, 7p
Abstrakt:	Background: The goal of the study is to ascertain how the pericardium and heart functions alter in patients with familial Mediterranean fever (FMF) both during the acute phase and the period of subclinical inflammation. Methods: During the study, 99 patients diagnosed with FMF (35 of whom were in an FMF attack period) were recruited to this study, and 24 completely healthy children in the same age group—who did not have FMF and had not any cardiac condition that applied to visit the pediatric cardiology outpatient clinic for routine follow-up—were included as the control group. Results: In patients with FMF, there was no discernible relationship between genetic abnormalities and pericardial thickness (p > 0.05). A significant difference was not observed in the diastolic and systolic cardiac function values between the control group and the FMF patients, with the exception of the parameters related to ejection time (ET), contraction time (IVCT), and relaxation time (IVRT). It was observed that pericardial thickness was greater in FMF patients than in study participants who did not have FMF, and this difference is statistically significant (p < 0.05). Conclusions: It was determined that the effects of cardiac inflammation continued in children with FMF, even if they were asymptomatic. Therefore, it should be part of the follow-ups. Key points: • In our study, cardiac functions and pericardial thickening of 99 FMF patients with and without attack were prospectively investigated. • In ongoing follow-up of patients with FMF, we found that inflammation, which affects all serosas, also affects the pericardium during the attract and nonattack phase. • We believe that cardiac functions, including the status of the pericardium, should be monitored as part of the long-term follow-up of FMF. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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