Physicochemical characteristics and antiproliferative activity of a water-soluble nanoformulation of the PtIV complex with a lonidamine-based ligand.

Autor:	Puchkov, A. A., Sedush, N. G., Nazarov, A. A., Chvalun, S. N.
Předmět:	BLOCK copolymers BIODEGRADABLE nanoparticles STAR-branched polymers CYTOTOXINS NANOCARRIERS ETHYLENE glycol
Zdroj:	Russian Chemical Bulletin; Jan2024, Vol. 73 Issue 1, p213-220, 8p
Abstrakt:	Water-soluble nanoformulation of a hydrophobic anticancer PtIV complex with a lonidamine-based ligand has been developed. Biodegradable nanocarriers (13 nm) obtained from poly(l-lactide-block-polyethylene glycol) star-shaped block copolymers were used to create the formulation. The loading of the active agent into nanoparticles was up to 3.7 wt.%, and the loading efficiency was up to 68%. It was shown that solubilization of the anticancer complex into polymeric nanoparticles did not lead to a significant decrease in its cytotoxicity. As the number of arms in the star-shaped block copolymers increased, the selectivity of the nanoformulations towards cancer cells tended to increase. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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