Synthesis of 4-(3-azidopropoxy)phenyl glycoside of tetraarabinofuranoside related to the terminal fragment of arabinogalactan and lipoarabinomannan of mycobacteria.

Autor:	Abronina, P. I., Karpenko, M. Yu., Malysheva, N. N., Zinin, A. I., Myachin, I. V., Kononov, L. O.
Předmět:	ARABINOGALACTAN MYCOBACTERIA AD hoc organizations AGLYCONES MYCOBACTERIUM tuberculosis GLYCOSIDES
Zdroj:	Russian Chemical Bulletin; Jan2024, Vol. 73 Issue 1, p189-203, 15p
Abstrakt:	A convergent synthesis of tetraarabinofuranoside β-d-Araf-(1→2)-α-d-Araf-(1→3)-α-d-Araf-(1→5)-α-d-Araf-1↑OR (R is 4-(3-azidopropoxy)phenyl) related to the terminal fragment of lipoarabinomannan (LAM) and arabinogalactan of mycobacteria was developed. The synthesized tetraarabinofuranoside represents a linear motif of a branched hexaarabinofuranoside, which is the main LAM epitope. 4-(3-Azidopropoxy)phenyl aglycone belongs to the class of Janus aglycones, which can serve as both a temporary protective group for the anomeric position of carbohydrate and a (pre)spacer for the synthesis of neoglycoconjugates useful for the development of new tuberculosis diagnostic assays. The key step of the synthesis is the formation of 1,2-cis-glycosidic bond. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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