| Abstrakt: |
Leishmaniasis is a protozoan zoonosis that causes problems in public health. The use of pentavalent antimony compounds as chemical drugs in the treatment of cutaneous leishmaniasis si associated with various limitations and side effects. Today, plant extracts and their derivations are the promising sources in herbal medicine. The purpose of this study was to evaluate the effectiveness of oil extract Pistacia atlantica Kurdistan province, Iran, on promastigotes of standard strain Leishmania major in vitro and in vivo. n this study, 10, 15, 25, and 50% concentrations of plant-based ointment were added to the lesions caused by promastigotes of Leishmania major. The effectiveness of treatment with different concentrations of pistacia extract on induced lesions at the base of the tail of Balb/c mice cultured with promastigotes of Leishmania major was checked in terms of disease progression or improvement and parasite load. The effect of 50% pistacia extract has the greatest effect on reducing the lesions diameter of Leishmania promastigotes, the results showed that there is a significant difference between the number of Leishmania major promastigotes in different concentrations of the extract and exposure time. With respect to the calculated P-value for time variable (P < 0.05), there was statistically remarkable difference among different time periods, so the mean of the measured lesion was different regarding 6 weeks of experiment, and there observed a statistically significant difference in terms of the time of lesion measurement. Additionally, the prediction, isolation, purification, and application of the effective compounds found in the Pistacia atlantica extract is highly suggested for future studies. [ABSTRACT FROM AUTHOR] |
