| Autor: |
Ebstrup, Malene Laage, Sønder, Stine Lauritzen, Fogde, Ditte Louise, Heitmann, Anne Sofie Busk, Dietrich, Tiina Naumanen, Dias, Catarina, Jäättelä, Marja, Maeda, Kenji, Nylandsted, Jesper |
| Předmět: |
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| Zdroj: |
Frontiers in Cell & Developmental Biology; 2024, p1-19, 19p |
| Abstrakt: |
Lysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 in lysosome repair, which operates independently of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. Our research reveals that Annexin A7 plays a role in repairing damaged lysosomes, different from its role in repairing the plasma membrane, where it facilitates repair through the recruitment of ESCRT-III components. Notably, our findings strongly suggest that Annexin A7, like the ESCRT machinery, is dispensable for membrane contact site formation within the newly discovered phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway. Instead, we speculate that Annexin A7 is recruited to damaged lysosomes and promotes repair through its membrane curvature and cross-linking capabilities. Our findings provide new insights into the diverse mechanisms underlying lysosomal membrane repair and highlight the multifunctional role of Annexin A7 in membrane repair. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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