| Autor: |
YU Haiyang, CHEN Qinhao, WANG Ziming, CAO Yueyue, PAN Yueyin |
| Předmět: |
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| Zdroj: |
Chinese Journal of Immunology; Jan2024, Vol. 40 Issue 2, p283-292, 6p |
| Abstrakt: |
Objective: To explore the relationship between CD1c gene expression and prognosis in breast cancer (BRCA) through TCGA database and GEO database. Methods: GEPIA, Kaplan-Meier Plotter and R software were used to comprehensively analyze and verify the function and role of CD1c. Expression level of CD1c in BRCA was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). Results: Compared with normal breast tissue, CD1c was lowly expressed in BRCA tissue. Kaplan-Meier survival analysis of samples from multiple datasets showed that patients in CD1c low expression group had a significantly worse overall prognosis. Immune correlation analysis revealed that CD1c had strong correlation with immature iDC cells, T cells, DC cells and B cells. The results of qRT-PCR showed that expression of CD1c was lower in BRCA tissues than in paired paracancer tissues (P<0.01) . IHC results showed that high CD1c expression was associated with longer PFS in patients (P=0.024). Conclusion: Low expression of CD1c is significantly correlated with the poor prognosis of BRCA patients, and its expression is closely related to immune infiltration, which may provide new help for the immunotherapy of BRCA patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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