| Abstrakt: |
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a dysfunction of the immune system. Mesenchymal stromal cell (MSCs) derived extracellular vesicles (EVs) are nanometer-sized particles carryinga diverse range ofbioactivemolecules, such as proteins, miRNAs, and lipids. Despite the methodological disparities, recent works onMSC-EVs have highlighted their broad immunosuppressive effect, thus driving forwards the potential of MSCEVs in the treatment of chronic diseases. Nonetheless, their mechanismof action is still unclear, and better understanding is needed for clinical application. Therefore, we describe in this review the diverse range of bioactive moleculesmediating their immunomodulatory effect, the techniques and possibilities for enhancing their immune activity, and finally the potential application to SLE. [ABSTRACT FROM AUTHOR] |
