| Autor: |
Kimura, Talita de Carvalho, de Lima-Souza, Reydson Alcides, Maciel, Tayná Figueiredo, Kowalski, Luiz Paulo, Coutinho‑Camillo, Cláudia Malheiros, Egal, Erika Said Abu, Altemani, Albina, Mariano, Fernanda Viviane |
| Zdroj: |
Head & Neck Pathology; 2024, Vol. 18 Issue 1, p1-16, 16p |
| Abstrakt: |
Background: Salivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs. Methods: This review provides a comprehensive literature review of the role of miRNAs expression in SGCs focusing on the diagnostic, prognostic, and therapeutic applications. Results: In this review, numerous dysregulated miRNAs have demonstrated an oncogenic and suppressor role in SGCs. Conclusion: In the future, these miRNAs may eventually constitute useful diagnostic and prognostic biomarkers that may lead to a better understanding of SGCs oncogenesis. Additionally, the development of therapeutic agents based on miRNAs may be a promising target in SGC treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink