| Autor: |
Ismaeel, Ahmed, Thomas, Nicholas T, McCashland, Mariah, Vechetti, Ivan J, Edman, Sebastian, Lanner, Johanna T, Figueiredo, Vandré C, Fry, Christopher S, McCarthy, John J, Wen, Yuan, Murach, Kevin A, von Walden, Ferdinand |
| Předmět: |
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| Zdroj: |
Function; 2024, Vol. 5 Issue 1, p1-11, 11p |
| Abstrakt: |
The central dogma of molecular biology dictates the general flow of molecular information from DNA that leads to a functional cellular outcome. In skeletal muscle fibers, the extent to which global myonuclear transcriptional alterations, accounting for epigenetic and post-transcriptional influences, contribute to an adaptive stress response is not clearly defined. In this investigation, we leveraged an integrated analysis of the myonucleus-specific DNA methylome and transcriptome, as well as myonuclear small RNA profiling to molecularly define the early phase of skeletal muscle fiber hypertrophy. The analysis of myonucleus-specific mature microRNA and other small RNA species provides new directions for exploring muscle adaptation and complemented the methylation and transcriptional information. Our integrated multi-omics interrogation revealed a coordinated myonuclear molecular landscape during muscle loading that coincides with an acute and rapid reduction of oxidative metabolism. This response may favor a biosynthesis-oriented metabolic program that supports rapid hypertrophic growth. Graphical Abstract [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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