DETERMINATION OF THE UTILITY OF ENDOMETRIAL TAO BRUSH IN THE DETECTION OF ENDOMETRIAL CANCER AND ATYPICAL HYPERPLASIA.
| Autor: | Kemei, E. J., Cheserem, E. J., Mungania, M., Mutua, J., Kyama, C. M. |
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| Předmět: |
CONFIDENCE intervals
CROSS-sectional method DILATATION & curettage EARLY detection of cancer HYPERPLASIA ENDOMETRIAL tumors DESCRIPTIVE statistics SENSITIVITY & specificity (Statistics) COLLECTION & preservation of biological specimens DATA analysis software WOMEN'S health LONGITUDINAL method EVALUATION |
| Zdroj: | East African Medical Journal; 2023, Vol. 100 Issue 9, p6279-6289, 11p |
| Abstrakt: | Background: Endometrial cancer is among the most common gynecologic malignancies in Kenya as it is in other developing countries. Screening using the Tao brush for direct sampling of the endometrium is a reliable technique for detecting lesions and can be done in an outpatient setting. These attributes enable early detection which is crucial for favorable outcomes, as over 90% of patients with early stages of endometrial cancer can be cured with treatment. Objective: To determine the Utility of Endometrial Tao brush in the detection of endometrial malignancies. Design: Prospective Cross-sectional Study. Setting: Department of Laboratory Medicine, Kenyatta National Hospital and Department of Obstetrics and Gynaecology, Kenyatta National Hospital. Study setting: Kenyatta National Hospital (KNH) gynecology Clinic. Measurable Variables: Independent variables included demographic and clinical data including; age, early menarche, late menopause, obesity, parity, and hypertension. Dependent variables included histopathological parameters of lesions; tumor size, type, tumor invasion, and metastasis. Results: Sixty women fulfilled the study entry criteria and were evaluated. Histopathological diagnoses comprised of; 14 (23%) Endometrial Cancers, 8 (13%) Complex hyperplasia with atypia, 16 (27%) Simple and mild hyperplasia without atypia, 3 (5%) Non-Diagnostic, and 19 (32%) patients with Negative Endometrial Histology. The specificity and sensitivity of cytology using Tao Brush were 100% and 95.45% respectively. The kappa value was 0.912. Conclusions: This study shows that endometrial Tao brush had a high specificity and sensitivity with a nearly perfect agreement with the dilatation and curettage samples. It therefore could have utility in most clinical settings in Kenya. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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