| Autor: |
Palomino-Fernández, David, Milara, Eva, Galiana, Álvaro, Sánchez-Ortiz, Miguel, Seiffert, Alexander P., Jiménez-Almonacid, Justino, Gómez-Grande, Adolfo, Ruiz-Solís, Sebastián, Ruiz-Alonso, Ana, Gómez, Enrique J., Tabuenca, María José, Sánchez-González, Patricia |
| Předmět: |
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| Zdroj: |
Applied Sciences (2076-3417); Feb2024, Vol. 14 Issue 4, p1454, 13p |
| Abstrakt: |
Evidence is emerging about the value of textural features as powerful outcome predictors in cancer lesions. The aim of this study is to evaluate the potential of [18F]FDG PET/CT conventional and textural parameters as survival predictors in patients with stage III and IV oropharyngeal cancer. The database includes 39 patients. Segmentation of the primary lesions was performed. A total of 48 features were extracted, comprising conventional parameters and textural features. A 2-year follow-up period to analyze the Overall Survival (OS) and Relapse-Free Survival (RFS) rates was defined. Kaplan–Meier and Cox proportional hazards regression analyses were computed. Higher TLG (p = 0.001) and Surface (p = 0.001) are significantly related to better OS in Cox regression analysis after multiple-testing correction. Higher GLZLM_ZLNU (p = 0.001) is significantly related to greater relapse rates in RFS Kaplan–Meier analysis after multiple-testing correction. Quantitative [18F]FDG PET/CT image features, especially the TLG, have been confirmed as predictors of OS and RFS. Textural features, such as GLZLM_ZLNU, demonstrated a potential predictive value for the OS and RFS of the patients. RFS analysis suggest stabilization of patients adhering to the treatment, showing no relapse events after 20 months of follow-up. [18F]FDG PET/CT is a useful tool for predicting prognosis after chemoradiation therapy of oropharyngeal cancer patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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