| Autor: |
Higgins, Courtney, Cohen, Noah D., Slovis, Nathan, Boersma, Melissa, Gaonkar, Pankaj P., Golden, Daniel R., Huber, Laura |
| Předmět: |
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| Zdroj: |
Veterinary Sciences; Feb2024, Vol. 11 Issue 2, p92, 16p |
| Abstrakt: |
Simple Summary: The role of the environment as a reservoir and source of antimicrobial resistance (AMR) is not fully understood. In this report, we explore the consequences of historical antimicrobial use in horse-breeding farms on the accumulation of antimicrobial residues in the environment and its impact on Rhodococcus equi populations carrying antimicrobial resistance genes (AMRGs). Understanding these relationships is important because the environment is the main source of R. equi infections of young horses. Moreover, the higher concentration of transferable AMRGs in the soil contributes to the emergence of pathogenic organisms carrying multidrug resistance that can affect humans and animals. This report reinforces how farm practices can have One Health impacts and suggests future research to investigate ways to mitigate the spread of AMR. Antimicrobial residues excreted in the environment following antimicrobial treatment enhance resistant microbial communities in the environment and have long-term effects on the selection and maintenance of antimicrobial resistance genes (AMRGs). In this study, we focused on understanding the impact of antimicrobial use on antimicrobial residue pollution and antimicrobial resistance (AMR) in the environment of horse-breeding farms. Rhodococcus equi is an ideal microbe to study these associations because it lives naturally in the soil, exchanges AMRGs with other bacteria in the environment, and can cause disease in animals and humans. The environment is the main source of R. equi infections in foals; therefore, higher levels of multidrug-resistant (MDR) R. equi in the environment contribute to clinical infections with MDR R. equi. We found that macrolide residues in the environment of horse-breeding farms and the use of thoracic ultrasonographic screening (TUS) for early detection of subclinically affected foals with R. equi infections were strongly associated with the presence of R. equi carrying AMRGs in the soil. Our findings indicate that the use of TUS contributed to historically higher antimicrobial use in foals, leading to the accumulation of antimicrobial residues in the environment and enhancing MDR R. equi. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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