| Autor: |
Cataldo, Alessandra, Cheung, Douglas G., Hagan, John P., Fassan, Matteo, Sandhu-Deol, Sukhinder, Croce, Carlo M., Di Leva, Gianpiero, Iorio, Marilena V. |
| Předmět: |
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| Zdroj: |
Non-Coding RNA; Feb2024, Vol. 10 Issue 1, p4, 9p |
| Abstrakt: |
MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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