| Autor: |
de Oliveira Silva, Daniele, Conceição Santos, Mário Ferreira, de Jesus Nicácio, Karen, Neto, Albert Katchborian, Ghilardi Lago, João Henrique, Chagas-Paula, Daniela Aparecida, Dias, Danielle F., Soares, Marisi G. |
| Předmět: |
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| Zdroj: |
Natural Product Research; Mar2024, Vol. 38 Issue 6, p1054-1059, 6p |
| Abstrakt: |
Owing to the potentially harmful adverse effects of current anti-inflammatory drugs, there is a need to identify new alternative substances. Thus, this study aimed to perform a phytochemical analysis of A. polyphylla to identify compounds responsible for its anti-inflammatory activity. Several fractions of the A. polyphylla extract were obtained and evaluated in an ex vivo anti-inflammatory assay using fresh human blood. Among the evaluated fractions, the BH fraction displayed the highest percentage of PGE2 inhibition (74.8%) compared to the reference drugs dexamethasone and indomethacin, demonstrating its excellent potential for anti-inflammatory activity. Astragalin (P1), a known 3-O-glucoside of kaempferol, was isolated from the A. polyphylla extract for the first time. In addition, a new compound (P2) was isolated and identified as the apigenin-3-C-glycosylated flavonoid. Astragalin showed moderate PGE2 activity (48.3%), whereas P2 was not anti-inflammatory. This study contributes to the phytochemical studies of A. polyphylla and confirms its anti-inflammatory potential. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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