| Autor: |
Petkau, Georg, Mitchell, Twm J., Evans, Marian Jones, Matheson, Louise, Salerno, Fiamma, Turner, Martin |
| Předmět: |
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| Zdroj: |
European Journal of Immunology; Feb2024, Vol. 54 Issue 2, p1-16, 16p |
| Abstrakt: |
How individual T cells compete for and respond to IL‐2 at the molecular level, and, as a consequence, how this shapes population dynamics and the selection of high‐affinity clones is still poorly understood. Here we describe how the RNA binding protein ZFP36L1, acts as a sensor of TCR affinity to promote clonal expansion of high‐affinity CD8 T cells. As part of an incoherent feed‐forward loop, ZFP36L1 has a nonredundant role in suppressing multiple negative regulators of cytokine signaling and mediating a selection mechanism based on competition for IL‐2. We suggest that ZFP36L1 acts as a sensor of antigen affinity and establishes the dominance of high‐affinity T cells by installing a hierarchical response to IL‐2. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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