Study on the Inhibitory Activity of Benzo[d]imidazo[2,1-b]thiazole Compounds Containing Chromone in Lung Cancer Cells.

Autor: Lujing, He, Ting, He, Longhui, Li, Xue, Jiang, Xiaoyan, Liu, Yuxin, Zhang, Shengjun, Li, Feng, Li, Qingsong, Zhou, Qidong, Tu, Jielian, Wu, Shanshan, Luo
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Zdroj: Russian Journal of Organic Chemistry; 2023 Suppl 1, Vol. 59, pS94-S100, 7p
Abstrakt: In recent years, lung cancer has become one of the most common malignant tumors in the world, which seriously threatens the life and health of mankind. Lung cancer is also the most common cancer in China. According to the latest report released by the National Cancer Center, the incidence and fatality rate of lung cancer in China rank first among malignant tumors, which has brought great disease burden to the Chinese. In this paper, using ethyl acetoacetate as the starting material, eight benzo[d]imidazolium[2,1-b]thiazole target compounds containing chromone were synthesized in five steps through alpha halogenation, cyclization, hydrolysis, condensation and cyclization reaction. MTT assay was used to evaluate the in vitro inhibitory activity of the target compounds on A549 and H2228 cancer cells. The IC50 values of the target compounds to A549 and H2228 cell lines ranged from 17.63 to 369.09 μmol/L. Some target compounds have moderate anti-tumor activity in vitro, which could be used to prepare related anti-tumor drugs for lung cancer. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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