| Autor: |
Kresina, T. F., Rosner, A., Goldbeg, V. M., Boja, Beata A., Moskowitz, R. W. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jul1984, Vol. 57 Issue 1, p63-72, 10p |
| Abstrakt: |
The effect of oestrogen or anti-oestrogen administration on gross pathology and in vitro cell-mediated immune responses to homologous lgG native and denatured interstitial collagens and PPD was studied in an JgG-induced rabbit model of immune synovitis. During induction of synovitis. rabbits were administered oestradiol valerate (0075 mg/kg/day) or tamoxifen. an anti-oestrogen (20 mg/kg/duy, high dose or 05 mg/kg/day. low dose) or placebo injections. Low dose tamoxifen administration was associated with significant improvement P<0115 in immune synovitis with regard to gross pathology. when compared to placebo and the oestradiol treatment group. High dose tamoxifen treatment was not associated with significant improvement in observed synovitis. With regard to cell-mediated immune responses. spleen cells derived from immune synovitis rabbits were observed to increase 3H-thymidine uptake on incubation with native or denatured homologous collagens. Modulation of these immune responses to antigens was observed in anti-oestrogen treated rabbits with immune synovitis. In regard cell-mediated immune responses to denatured type I, II and III collagens, PPD. as well as native type II and II collagens were not observed in the low dose tamoxifen treatment group. However, In ritro immune responses to these antigens were observed in spleen cell cultures from immune synovitis rabbits treated with either high dose tamoxifen or oestradiol valerate. The data suggest that in vivo anti-oestrogen administration can modulate the in vitro cell-mediated immune response to connective tissue constituents observed in immune synovitis. Concomitant with reduced immune responses is a significant reduction in the observed lesions of the inflammatory response. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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