Researchers from Metropolitan Autonomous University Iztapalapa Report on Findings in Dengue Hemorrhagic Fever (in Vitro And In Silico Studies of Bis-furyl-pyrrolo[3,4-b]Pyridin-5-ones On Dengue Virus).

Předmět:	DENGUE hemorrhagic fever DENGUE viruses RESEARCH personnel RNA virus infections RENILLA luciferase
Zdroj:	Zika & Mosquito Week; 2024, p3041-3041, 1p
Abstrakt:	Researchers from Metropolitan Autonomous University Iztapalapa in Mexico have conducted in vitro and in silico studies on bis-furyl-pyrrolo[3,4-b]pyridin-5-ones and their potential activity against Dengue virus. The compounds 1a and 1b were found to reduce the expression of Renilla luciferase and decrease viral load, indicating potential antiviral activity against Dengue virus serotype 4. In silico simulations also showed that compound 1a was the best ligand. These findings suggest that two of the synthesized compounds have potential antiviral activity against Dengue virus in vitro. The research has been peer-reviewed and published in the Journal of the Mexican Chemical Society. [Extracted from the article]
Databáze:	Complementary Index
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