| Abstrakt: |
This document is a patent application that describes mutant forms of the protein interleukin-21 (IL-21) and their potential uses. The mutant proteins have specific amino acid substitutions, deletions, or truncations compared to the wild-type IL-21 protein. These mutations can result in improved properties such as lower affinity for IL-21 receptors, higher stability, improved druggability, and increased selective activation of specific cells. The mutant proteins can also be fused with other proteins, such as Fc fragments or antibodies, for various therapeutic applications. The patent application provides detailed sequences and combinations of mutations for the mutant proteins. [Extracted from the article] |
