| Abstrakt: |
Researchers at Ruhr-University Bochum in Germany have developed a new rat model to study global cerebral hypoxia, a condition that can lead to significant disability in humans. The model involves using the muscle blocking agent rocuronium to induce respiratory insufficiency in anesthetized rats, followed by administration of sugammadex to reverse the effects of rocuronium. The study found that the hypoxic rats showed significant morphological and biochemical changes in the hippocampus and cerebellum, with more pronounced effects in females. The researchers concluded that this model can be used to investigate therapeutic and preventive drugs for global cerebral hypoxia. [Extracted from the article] |
