| Abstrakt: |
Researchers from Linkoping University in Sweden have developed a novel Drosophila model of Alzheimer's disease to study the proteotoxicity of amyloid-beta (Ab) peptides in the digestive tract. The model allows for the screening of anti-Ab proteotoxic agents and the identification of substances that can modify Ab proteotoxicity. By expressing different variants of Ab1-42 in the flies, the researchers observed reduced longevity, aggregate deposition, and the presence of apoptotic cells. This gut-based fly model provides insights into the mechanisms behind Ab proteotoxicity and may contribute to the development of novel treatments for Alzheimer's disease. [Extracted from the article] |
