Assessing the Burden of COVID-19 among Children Aged 6-14 Years in Karnataka, India: A Cross-sectional Survey.
| Autor: | Rajagopal, Padma M., Sil, Satyam, Dinesh, Prameela, Shiju, Shilpa, D. P., Arunkumar, Ramaiah, Srinivas S., R., Hande Lalitha, T., Mamatha, P., Ainapure Kantinath, Pujari, Lokesh, B. S., Pradeep, Shenoy, Anusha B., Desai, Anita, Munivenkatappa, Ashok, Gudi, Chetan S., Babu, Giridhara R., Sudarshan, M. K. |
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| Předmět: |
RESEARCH
SEROPREVALENCE CLUSTER sampling REVERSE transcriptase polymerase chain reaction COVID-19 SAMPLE size (Statistics) SEQUENCE analysis GENETIC mutation COVID-19 vaccines CROSS-sectional method REINFECTION SEVERITY of illness index SURVEYS GENOME-wide association studies GENOMICS ENZYME-linked immunosorbent assay IMMUNOENZYME technique DESCRIPTIVE statistics RESEARCH funding MICROBIAL virulence DATA analysis software DISEASE risk factors CHILDREN |
| Zdroj: | Indian Journal of Community Medicine; Jan/Feb2024, Vol. 49 Issue 1, p110-104, 5p |
| Abstrakt: | Background: India experienced three coronavirus disease (COVID-19) waves, with the third attributed to the highly contagious Omicron variant. Before the national vaccination rollout for children above 6, understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) positivity in the pediatric population was essential. This study aims to assess the burden of Covid-19 infection and to estimate the seroprevalence in children aged 6 to 14 years in the state of Karnataka. Material and Methods: We surveyed 5,358 children aged 6-14 across Karnataka using 232 health facilities, from June 6 to 14, 2022. We determined the sample size using the PPS (Population Proportional to Size) technique and employed cluster sampling. We tested all participants for SARS-CoV-2 IgG with an enzyme-linked immunosorbent assay (ELISA) kit and SARS-CoV-2 RNA with reverse transcription-polymerase chain reaction (RT-PCR). We sequenced samples with a cycle threshold (CT) value below 25 using whole genomic sequencing (WGS). Result: We found an adjusted seroprevalence of IgG at 75.38% statewide, and we found 0.04% of children RT-PCR positive for COVID-19. We determined a case-to-infection ratio of 1:37 and identified the SARS-CoV-2 strains as Omicron, BA.5, and BA.2.10. Conclusion: The study showed a high seroprevalence of IgG among children with low active infection. Omicron, BA. 5, and BA. 2.10 variants were detected through WGS. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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