Salivary Cortisol Levels and Clinical Signs of Stress in Premature Neonates Treated with Vimala Massage: A Randomized Controlled Trial.
| Autor: | González, Alma Patricia, Loredo Aguayo, Claudia Helena, Barbosa Sabanero, Gloria, Vasquez Mendoza, Ma Guadalupe, Aguiñaga Zamarripa, Ma de La Luz, Linares Salas, Victor Hugo, Sosa Bustamante, Gloria Patricia |
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| Předmět: |
SALIVA analysis
HUMAN growth NONPARAMETRIC statistics INFANT care MASSAGE therapy NEONATAL intensive care ANALYSIS of variance CONFIDENCE intervals FOOD consumption GESTATIONAL age RESPIRATORY measurements MANN Whitney U Test OXYGEN saturation RANDOMIZED controlled trials IMMUNOASSAY WEIGHT gain T-test (Statistics) ENZYME-linked immunosorbent assay HEART beat DESCRIPTIVE statistics STATISTICAL sampling DATA analysis software HYDROCORTISONE STRESS in children PATIENT safety CHILDREN |
| Zdroj: | Journal of Integrative & Complementary Medicine; Feb2024, Vol. 30 Issue 2, p165-172, 8p |
| Abstrakt: | Background: In neonatal intensive care units across the world, premature neonates are exposed to a very stressful environment with high levels of noise, bright lights, pain, infections, invasive procedures, and a lack of maternal contact. Stress is manifested by increased cortisol levels and clinical signs of stress. Objective: To assess the impact of Vimala massage on (1) salivary cortisol levels (primary outcome) and (2) clinical signs of stress (secondary outcomes) in premature neonates. Methods: Neonates (28–36 weeks gestational age) admitted to a nursery unit were randomized one-to-one to receive 15–20 min of Vimala massage administered by their parents twice daily and usual care, or to usual care alone. Salivary cortisol levels were measured by enzyme-linked immunosorbent assay (ELISA) on days 1 and 5. Heart rate, respiratory rate, caloric intake, weight gain, and growth were recorded daily. Groups were compared with t tests, U-tests, and repeated measures analysis of variance. Results: Seventy neonates, 35 in each group, were included. Groups were comparable at baseline. The median decrease in salivary cortisol levels was 0.12 μg/dL in the massage group and 0.07 μg/dL in the control group (p = 0.22). Over 5 days, the massage group had significant decreases in resting heart rate (p = 0.003) and respiratory rate (p = 0.028), and greater weight gains (p = 0.0002), relative to controls. Conclusions: In this randomized trial, adding Vimala massage to usual nursery care was not associated with a significant decrease in salivary cortisol levels in premature neonates, when compared with usual nursery care alone. There were improvements in clinical signs of stress. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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