| Autor: |
Zhang, Zhenye, Cheng, Nan, Liang, Jianfen, Deng, Yifan, Xiang, Ping, Hei, Ziqing, Li, Xiang |
| Předmět: |
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| Zdroj: |
Annals of Medicine; 2023, Vol. 55 Issue 2, p1-16, 16p |
| Abstrakt: |
An increasing number of studies show that the intestinal flora is closely related to spinal cord injury. Many researchers are exploring the changes in the richness, diversity, and evenness of intestinal flora in spinal cord injury animal models to identify the characteristic bacteria. A comprehensive literature search was conducted using three databases: PubMed, Embase, and Web of Science. A meta-analysis was performed using R 4.3.1 to evaluate the comparison of microbiota diversity, richness, and evenness and the relative abundance of intestinal microbiota in animals with spinal cord injury and blank controls. Fifteen studies were included in the meta-analysis, of which 12 involved gut microbiota distribution indicators and 11 included intestinal microflora relative abundance indicators. Meta-analysis of high-dimensional indicators describing the distribution of the gut microbiota identified a substantial decline in the evenness and richness of the intestinal flora. In addition, the Actinobacteria phylum and Erysipelotrichales and Clostridiales orders were significantly different between the spinal cord injury and sham groups; therefore, they may be the characteristic bacteria in spinal cord injury models. Our meta-analysis suggested that the gut microbiota in the spinal cord injury animal model group was altered compared with that in the control group, with varying degrees of changes in richness and evenness and potentially pathogenic characteristic flora. More rigorous methodological studies are needed because of the high heterogeneity and limited sample size. Further research is needed to clinically apply intestinal microbiota and potentially guide fecal microbiota transplantation therapy. Our meta-analysis showed that spinal cord injury significantly decreased the richness and evenness of intestinal flora in experimental animals. No statistically significant changes in the phyla flora during spinal cord injury have been found. Erysipelotrichales and Clostridiales may be the characteristic flora of gut microbiota changes during spinal cord injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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