| Autor: |
Al Assaad, Majd, Shin, Nara, Sigouros, Michael, Manohar, Jyothi, Antysheva, Zoia, Kotlov, Nikita, Kiriy, Daria, Nikitina, Anastasiia, Kleimenov, Mikhail, Tsareva, Anastasiya, Makarova, Anastasiya, Fomchenkova, Victoria, Dubinina, Julia, Boyko, Alexandra, Almog, Nava, Wilkes, David, Escalon, Joanna G., Saxena, Ashish, Elemento, Olivier, Sternberg, Cora N. |
| Předmět: |
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| Zdroj: |
Frontiers in Oncology; 2024, p1-8, 8p |
| Abstrakt: |
Cancer of unknown primary (CUP) represents a significant diagnostic and therapeutic challenge, being the third to fourth leading cause of cancer death, despite advances in diagnostic tools. This article presents a successful approach using a novel genomic analysis in the evaluation and treatment of a CUP patient, leveraging whole-exome sequencing (WES) and RNA sequencing (RNA-seq). The patient, with a history of multiple primary tumors including urothelial cancer, exhibited a history of rapid progression on empirical chemotherapy. The application of our approach identified a molecular target, characterized the tumor expression profile and the tumor microenvironment, and analyzed the origin of the tumor, leading to a tailored treatment. This resulted in a substantial radiological response across all metastatic sites and the predicted primary site of the tumor. We argue that a comprehensive genomic and molecular profiling approach, like the BostonGene© Tumor Portrait, can provide a more definitive, personalized treatment strategy, overcoming the limitations of current predictive assays. This approach offers a potential solution to an unmet clinical need for a standardized approach in identifying the tumor origin for the effective management of CUP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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