| Autor: |
Rosalia, Luca, Ozturk, Caglar, Wang, Sophie X., Quevedo‐Moreno, Diego, Saeed, Mossab Y., Mauskapf, Adam, Roche, Ellen T. |
| Předmět: |
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| Zdroj: |
Advanced Functional Materials; Feb2024, Vol. 34 Issue 8, p1-13, 13p |
| Abstrakt: |
Heart failure with preserved ejection fraction (HFpEF) is a major challenge in cardiovascular medicine, accounting for ≈50% of all cases of heart failure. Despite the ongoing efforts, no medical device has yet received FDA approval. This is largely due to the lack of an in vivo model of the HFpEF hemodynamics, resulting in the inability to evaluate device effectiveness in vivo prior to clinical trials. Here, the development of a highly tunable porcine model of HFpEF hemodynamics is described using implantable soft robotic sleeves, where controlled actuation of a left ventricular and an aortic sleeve can recapitulate changes in ventricular compliance and afterload associated with a broad spectrum of HFpEF hemodynamic phenotypes. The feasibility of the proposed model in preclinical testing is demonstrated by evaluating the hemodynamic response of the model post‐implantation of an interatrial shunt device, which is found to be consistent with findings from in silico studies and clinical trials. This work overcomes limitations of prior HFpEF models, such as low hemodynamic accuracy, high costs, and long development phases. The versatile and adjustable platform introduced can transform HFpEF device development, aiming to enhance the lives of the 32 million people affected globally. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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