| Autor: |
Kellaway, C. H., Rawlinson, W. A. |
| Zdroj: |
Australian Journal of Experimental Biology & Medical Science; Jun1944, Vol. 22 Issue 2, p63-68, 6p, 2 Charts |
| Abstrakt: |
During saline perfusion of the isolated lungs of the guinea-pig, tissue injury manifested by the liberation of histamine occurred within sis hours at 43°C., but not at 41°C. In eighteen experiments at 45°C., in nine of which the lungs were ventilated as uniformly as possible with air, and in nine with nitrogen, the latter group did not show a significantly greater output of histamine during perfusion for six hours. More vigorous ventilation with air, oxygen or nitrogen in six experiments gave larger percentage outputs of histamine during six hours perfusion at 45°, and even in these conditions the observed variations in histamine output were clearly related to variation in the degree of ventilation. Our results show that anoxia does not cause gross injury to tissue cells and suggest that it is unlikely to aggravate heat injury to a significant extent. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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